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These studies will also need to account for interactions among smoking, biological aging, sex, genetics, and comorbidities that influence immune trajectories

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Extending the follow-up period to 5 or 10 years could provide a more comprehensive understanding of the long-term metabolic risks, as metabolic syndrome and its components, such as obesity and hypertension, often develop over an extended period

Research has linked the use of smokeless tobacco to cancer and other diseases of the mouth, and with heart disease and stroke