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In multivariate MR, the SNPs utilized as IVs must satisfy the following conditions: 1) they should be associated with all exposure factors in the model, 2) they should not impact the outcome variables through alternative pathways, and 3) the number of SNPs should exceed the number of exposure factors

In his later career Xie worked primarily for two large Chinese-owned tobacco companies, the Nanyang Brothers Tobacco Company and the Huacheng Tobacco Company