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The strategy hinges on portfolio segmentation: the entry level 3 milligram pouches aim to attract cigarette smokers wary of high nicotine doses, while the 6 milligram and stronger variants cater to heavy users familiar with the quick absorption of moist snuff

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Jaakkola and colleagues [25] examined the relationship between exposure to ETS and development of respiratory symptoms including dyspnea, in a population of 117 subjects who had never smoked and who were aged between 15 and 40 at the time of initial examination, and who were reexamined eight years later

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