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It is driven by the production and deposition of amyloid peptide and intracellular accumulation of neurofibrillary tangles of hyperphosphorylated protein ( Cigarette smoking was associated with risk biomarkers for Alzheimers disease characterized by excessive OxS, neuroinflammation, and elevated -amyloid 42 levels in a case-control study in humans (Liu et al., 2020)

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However, the actor himself is not a smoker, which makes the fact that he went through thousands of cigarettes over the course of the show even more striking