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Activation of nicotine-7nAChR signaling can trigger membrane depolarization, which activates voltage-gated calcium channels and subsequently activates the MAPK pathway, possibly increasing B-cell lymphoma-2 (Bcl-2) expression and apoptosis downregulation [111]
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Just weeks ago, government officials released data showing that the percentage of high-schoolers who had tried e-cigarettes had doubled to 10 percent between 2011 and 2012
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