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At the same time, increased scrutiny of marketing claims, as reflected in the June 2026 Italian competition authority action against Philip Morris Italia over smoke-free marketing claims, rewards brands that build substantiation workflows and tailor localized messaging to tightening advertising and consumer-protection expectations

Smokers can therefore be reassured and encouraged to use them, and the public can be reassured that e-cigarettes are much safer than smoking

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There was no apparent age-dependence, and no notable increase in C max or AUC upon multiple dosing (10 mg/kg three times a day)