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This is because all NSAIDs share similar mechanisms of action and can potentiate each other's side effects when used at the same time, and, according to Healthline, ibuprofen even comes with boxed warnings from the FDA about its risk of causing severe GI side effects

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National data from 2018 on individuals aged 15 to 24 indicate that alcohol was the most commonly used substance across the lifespan (59.6%), followed by cigarettes (24.6%), marijuana (18.9%), and other illicit drugs (3.5%) (10)

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