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The UN Sustainable Development Goals (SDG) Article 12.4 specifically refers to the 2020 goal of achieving the environmentally sound management of chemicals and all wastes throughout their life cycle, while Article 3a explicitly calls to [s]trengthen the implementation of the WHO Framework Convention on Tobacco Control in all countries, as appropriate (United Nations 2015b)

RING0-mediated substrate interactions have been observed in several studies with the K161N mutation 44,45

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