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Prior to the latest ruling, makers of HTP like IQOS were able to import and sell these devices legally using a loophole in the law called habeas corpus trials. But the loophole prevented the development of a fully regulated, legal market

Longterm CSE exposure (5% CSE for 10 weeks) decreased mitochondrial respiration in human bronchial epithelial BEAS-2B cells, which was accompanied by significantly increased mitochondrial gene expression levels compared to CSE unexposed controls, while the methylation levels remained unaffected

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