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In particular, some substances present in traditional cigarette smoke, such as polycyclic aromatic hydrocarbons (PAHs), acetone, pyridine, heavy metals, benzene, carbon monoxide, nicotine, can influence absorption, distribution, metabolism and elimination of a drug and it can alter the response of the cellular receptors on which they act, resulting in changes of the effectiveness and safety of pharmacological treatments

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For Francona, every stepminor leagues to majorswas another page in his long baseball gospel