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Harmine may exert its effects through direct interaction with ion channels or indirectly by modulating other signaling pathways that ultimately lead to the changes of membrane potential

In addition, cotinine at 10 M was found to lack significant binding to or action on more than 70 molecular targets, including major neurotransmitter receptors and transporters (adenosine, adrenergic, dopamine, GABA, glutamate, glycine, histamine, muscarinic, opioid, serotonin, sigma 1 and 2), ion channels (Ca 2+ , K + , Na + ), second messengers (e.g., nitric oxide), prostaglandins (e.g., leukotriene and thromboxane), brain/gut peptides (e.g., angiotensin II, bradykinin, endothelin, neurokinin, neuropeptide), and enzymes (acetylcholine esterase, phosphodiesterase, protein kinase A and C) (Terry et al., 2015a)

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The companys strategy has evolved from product-centric to purpose and audience-centric, creating resonance across markets