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With this caffeine-induced stress magnifier, the risk of vasospasm is increased.44 Caffeine also contributes to magnesium deficiency, a condition that makes arteries more prone to spasm.45 In typical vicious-cycle fashion, the combination of caffeine and stress exacerbates the low magnesium state.46 Whats more, if there is also a buildup of plaque within the artery, the tendency for arteries to spasm increases the overall risk for heart attack tremendously