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Upon exposure to oxidative stress, the sequestration complex brakes down and the dissociated Nrf2 translocates into the nucleus, where it binds to cis-acting antioxidant response elements and promotes the transcription of a large number of cytoprotective genes (56, 57)

Smoking is harmful and affects all organs, including the liver, which is responsible for detoxification

10.1016/j.drugalcdep.2017.07.035 10

(that's right) Yeah, and what they call work is digging in the dirt Gotta get it in the ground 'fore the rain come down To get paid, to get the girl In your four-wheel drive (a country boy can survive) Yeah the boys 'round here Drinkin' that ice cold beer Talkin' 'bout girls, talkin' 'bout trucks Runnin' them red dirt roads out, kicking up dust The boys 'round here Sending up a prayer to the man upstairs Backwoods legit, don't take no shit Chew tobacco, chew tobacco, chew tobacco, spit Aw heck Red red red red red red red red red redneck Well the boys 'round here, they're keeping it country Ain't a damn one know how to do the dougie