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Abbreviations ad lib : Ad lib itum AE: Adverse event AUC: Area under the concentration-time curve AUEC: Area under the effect curve CO: Carbon monoxide CRO: Contract Research Organization e-Cigarettes: Electronic cigarettes FTCD: Fagerstrm test for cigarette dependence Kg: Kilogram LC-MS/MS: Liquid chromatography-tandem mass spectrometry mg: Milligram mm: Millimeter mL: Milliliter ng: Nanogram PD: Pharmacodynamics PK: Pharmacokinetic PG: Propylene glycol ppm: Parts per million USP: United States Pharmacopeia VAS: Visual analog scale References U.S

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In comparison to 2018, the ratio of very satisfied patients vs