Tobacco-specific nitrosamines (TSNAs), particularly N-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), which are present at high concentrations in most smokeless tobacco products, are classified as carcinogenic to humans (Group 1) by the International Agency for Research on Cancer (28)
In his "American Notes (1877)," Dickens describes a country awash in tobacco - an exaggeration of nastiness, which cannot be outdone. As Washington may be called the head-quarters of tobacco-tinctured saliva, the time is come when I must confess, without any disguise, that the prevalence of those two odious practices of chewing and expectorating began about this time to be anything but agreeable, and soon became most offensive and sickening. Dickens American Notes was illustrated by the American editorial cartoonist - Thomas Nast
Nicotine aggravates liver fibrosis via alpha7 nicotinic acetylcholine receptor expressed on activated hepatic stellate cells in mice
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