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Roll-your-own shops use pipe tobacco which is taxed at a much lower rate

However, while valuable, this model had key limitations, including a lack of reproducible smoke dose delivery, the inability to assess cigarette smoke-induced toxicity in the distal lung, and the absence of essential readouts like trans-barrier electrical resistance (TER), restricting its applicability for studying alveolar-level injuries

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Despite drug discontinuation, 1 participant receiving varenicline and 1 participant receiving bupropion 300 mg/day remained abstinent at Weeks 812 (Supplementary file Table 4)