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Such a framework would need to compare different types of harm (e.g., disease, dependence, and bystander risk) arising over different periods (immediate, intermediate, and long-term), affecting different subpopulations (e.g., youth smokers, nonsmokers, adults, and deprived groups), caused by diverse products spanning a risk continuum of several orders of magnitude (e.g., cigarettes, vapes, and pouches), and used over varying periods (e.g., decades of heavy use vs