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The IARC classifies chemicals, air pollution, pharmaceuticals and behaviors, all of which are referred to as agents, into four categories based on whether existing scientific research shows the agent in question is capable of causing cancer in humans

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Additionally, since there were few never-smoking adults who used ECs, the ability to detect significant associations with respiratory symptoms may have been limited, calling for future research to seek out larger samples of adults who use ECs but never-smoked cigarettes